Surgery Websites
Pediatric Surgery Lab »  People »  Principal Investigators »  Tippi MacKenzie, M.D.

Tippi MacKenzie, M.D.

Professor of Surgery
Division of Pediatric Surgery
Co-director, UCSF Center for Maternal-Fetal Precision Medicine
UCSF Benioff Children's Hospital, San Francisco



Contact Information

Open Popup
  • 1987-91, Harvard University, B.A., Biochemistry
  • 1992-97, Stanford University School of Medicine, M.D., Medicine
  • 1998-99, Brigham and Women's Hospital, Resident, Surgery
  • 2002-04, Brigham and Women's Hospital, Resident, Surgery
  • 2004-05, Brigham and Women's Hospital, Chief Resident, Surgery
  • 1999-02, Children's Hospital of Philadelphia, Fellow, Fetal Therapy
  • 2005-07, Children's Hospital of Philadelphia, Fellow, Pediatric Surgery
  • American Board of Surgery, 2006
  • Fetal Treatment Center
  • Biomedical Sciences Program
  • Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
  • Center for Maternal-Fetal Precision Medicine
  • Advanced Laparoscopy
  • Birth Defects
  • Endocrine and Biliary Surgery
  • Fetal Surgery
  • Pediatric Surgery
  • In-Utero Stem Cell Transplantation

Dr. Tippi MacKenzie is Professor of Surgery at the UCSF Division of Pediatric Surgery and the Fetal Treatment Center. Dr. MacKenzie obtained her undergraduate degree in Biochemistry at Harvard, then came to the Bay Area for medical school at Stanford. She did her surgical residency at Brigham and Women's Hospital in Boston. During this time, she took three years to do research on fetal surgery and in utero stem cell transplantation at the Children's Hospital of Philadelphia. Following residency, she returned to CHOP for her clinical pediatric surgery fellowship.

Dr. MacKenzie's clinical interests include fetal surgery, advanced laparoscopy, and endocrine and biliary surgery.

Dr. MacKenzie has an active laboratory and is a member of the Biomedical Sciences Program and the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research. Her research focus is on mechanisms of tolerance induction following in utero stem cell transplantation  and the pathophysiology of prenatally diagnosed diseases, such as congenital diaphragmatic hernia and gastroschisis, to identify biomarkers that predict prognosis and molecular pathways that may be targets for prenatal intervention.

Data provided by UCSF Profiles, powered by CTSI
  • Autoimmune Regulator gene (Aire)-mediated tolerance to pregnancy-associated self-antigens
    Sponsor:
    Sponsor ID:
    Funding Period:
    Aug 2019
    -
    Jul 2024
    Principal Investigator
  • In utero hematopoietic stem cell transplantation for the treatment of fetuses with alpha thalassemia major (phase I clinical trial)
    Sponsor:
    Sponsor ID:
    Funding Period:
    Aug 2017
    -
    Jul 2022
    Principal Investigator
  • A precision medicine approach to detect dysbiosis and immune activation in preterm labor
    Sponsor:
    Sponsor ID:
    Funding Period:
    Jul 2017
    -
    Jun 2021
    Principal Investigator
  • T cell activation and the breakdown of maternal-fetal tolerance in preterm labor
    Sponsor:
    Sponsor ID:
    Funding Period:
    Jun 2015
    -
    May 2020
    Principal Investigator
  • Maternal and fetal immune responses to in utero HSC transplantation
    Sponsor:
    Sponsor ID:
    Funding Period:
    Jul 2010
    -
    May 2015
    Principal Investigator
  • IN UTERO MESENCHYMAL STEM CELL TRANSPLANTATION
    Sponsor:
    Sponsor ID:
    Funding Period:
    Jan 2000
    -
    Jan 0001
    Principal Investigator
Data provided by UCSF Profiles, powered by CTSI
MOST RECENT PUBLICATIONS FROM A TOTAL OF 83
Data provided by UCSF Profiles, powered by CTSI
  1. Schwab ME, MacKenzie TC. Prenatal Gene Therapy. Clin Obstet Gynecol. 2021 Dec 01; 64(4):876-885. View in PubMed
  2. Le BL, Sper R, Nielsen SCA, Pineda S, Nguyen QH, Lee JY, Boyd SD, MacKenzie TC, Sirota M. Maternal and Infant Immune Repertoire Sequencing Analysis Identifies Distinct Ig and TCR Development in Term and Preterm Infants. J Immunol. 2021 Oct 15. View in PubMed
  3. Schwab ME, Dong S, Lianoglou BR, Aguilar Lucero AF, Schwartz GB, Norton ME, MacKenzie TC, Sanders SJ. Exome sequencing of fetuses with congenital diaphragmatic hernia supports a causal role for NR2F2, PTPN11, and WT1 variants. Am J Surg. 2021 Jul 20. View in PubMed
  4. Gillis-Buck E, Miller H, Sirota M, Sanders SJ, Ntranos V, Anderson MS, Gardner JM, MacKenzie TC. Extrathymic Aire-expressing cells support maternal-fetal tolerance. Sci Immunol. 2021 Jul 16; 6(61). View in PubMed
  5. Bianchi DW, Khosrotehrani K, Way SS, MacKenzie TC, Bajema I, O'Donoghue K. Forever Connected: The Lifelong Biological Consequences of Fetomaternal and Maternofetal Microchimerism. Clin Chem. 2021 01 30; 67(2):351-362. View in PubMed
  6. View All Publications

 

Site Directory
    X